Neuroprotective effects of digested polyphenols from wild blackberry species
Purpose
Blackberry ingestion has been demonstrated to attenuate brain degenerative processes with the benefits ascribed to the (poly)phenolic components. The aim of this work was to evaluate the neuroprotective potential of two wild blackberry species in a neurodegeneration cell model and compare them with a commercial variety.
黑莓的摄入已经被证明可以减弱大脑退化过程的好处归因于(多)酚成分。这项工作的目的是评估两种野生黑莓在神经退化细胞模型中的神经保护潜力，并将它们与商业品种进行比较。
Results
The three blackberry extracts presented some quantitative differences in polyphenol composition that could be responsible for the different responses in the neurodegeneration cell model. Commercial blackberry extracts were ineffective but both wild blackberries, Rubus brigantinus and Rubus vagabundus, presented neuroprotective effects. It was verified that a diminishment of intracellular ROS levels, modulation of glutathione levels and activation of caspases occurred during treatment. The last effect suggests a preconditioning effect since caspase activation was not accompanied by diminution in cell death and loss of functionality.
三种黑莓提取物的多酚组成存在一定的数量差异，这可能是神经退化细胞模型中不同反应的原因。商业黑莓提取物无效，但野生黑莓，蓝莓和野莓，有神经保护作用。实验证实，在治疗过程中，细胞内ROS水平降低，谷胱甘肽水平调节，caspases活化。最后一种效应表明是一种预处理效应，因为caspase激活并不伴随着细胞死亡的减少和功能的丧失。
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