Effects of blackberry (Morus nigra) fruit juice on levodopa-induced dyskinesia in a mice model of Parkinson’s disease
Background and objective
Levodopa-induced dyskinesia (LID) is a movement disorder that occurs due to levodopa consumption for a long period to attenuate Parkinsonism. Plants have been the basis for medical treatments in human history and still widely practiced. Blackberry (Morus nigra) is one of the fruits rich in anthocyanin. The present study examined the effect of blackberry fruit juice on LID in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson’s disease in mice.
左旋多巴诱发运动障碍(LID)是一种由于长期服用左旋多巴以减轻帕金森病而发生的运动障碍。植物在人类历史上一直是医学治疗的基础，至今仍被广泛使用。黑莓(Morus nigra)是一种富含花青素的水果。本研究检测了黑莓果汁对1-甲基-4-苯基-1,2,3,6-四氢吡啶(MPTP)诱导的帕金森病小鼠LID的影响。
Results
Parkinson’s disease was confirmed with AIMS test on the fourth day after MPTP injection. The onset of LID was observed after 2 weeks of levodopa treatment using both behavioral tests. The result of administration of M. nigra fruit juice for 1 week showed that this addition is useful in hindering LID. These effects were more pronounced at doses 10 and 15 mL/kg with nearly the same results on attenuating AIMS. Low dose of the fruit juice does not seem to affect LID significantly.
注射MPTP后第4天经AIMS检查确诊帕金森病。用两种行为测试方法观察左旋多巴治疗2周后LID的发病情况。结果表明，添加黑莓果汁1周对LID有一定的抑制作用。当剂量为10和15 mL/kg时，这些影响更为明显，而降低AIMS的结果几乎相同。低剂量的果汁似乎对LID没有显著影响。
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