Dietary polyphenols: Structures, bioavailability and protective effects against atherosclerosis

Abstract

Epidemiological studies have demonstrated that nutritional habits, like those based on high consumption of fruits and vegetables, have been associated with a longer life expectancy and a significant decrease in the incidence and prevalence of several chronic diseases with inflammatory basis, such as cardiovascular diseases (CVD). This beneficial activity has been related to the content of several bioactive compounds in fruit and vegetables, such as polyphenols. The cardioprotective effects of polyphenols have been linked mainly to its antioxidant properties; however, recent findings attribute its anti-atherosclerotic potential to modulate simultaneous signaling and mechanistic pathways. Emerging data suggest that polyphenols can regulate cellular lipid metabolism; vascular and endothelial function; haemostasis; as well as platelet function; which represent primary conditions for atherosclerotic plaque formation and development. This review presents the results of a selection of experimental studies and clinical trials regarding the atheroprotective effects of the most common dietary polyphenols.

 

流行病学研究表明，营养习惯，比如那些大量食用水果和蔬菜的习惯，与预期寿命的延长和若干炎症性慢性疾病(如心血管疾病)的发病率和流行率的显著降低有关。这种有益的活性与水果和蔬菜中多种生物活性化合物的含量有关，如多酚。多酚的心脏保护作用主要与它的抗氧化特性有关;然而，最近的研究发现，其抗动脉粥样硬化的潜力是调节同时信号和机制途径。新的数据表明，多酚可以调节细胞脂质代谢;血管和内皮功能;止血;以及血小板功能;这是动脉粥样硬化斑块形成和发展的主要条件。这篇综述介绍了一组关于最常见膳食多酚对动脉粥样硬化保护作用的实验研究和临床试验结果。

 

 

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https://www.sciencedirect.com/science/article/abs/pii/S027869151830022X