Dietary polyphenols regulate endothelial function and prevent cardiovascular disease
Abstract
Vascular endothelial cell (EC) dysfunction strongly induces development of cardiovascular and cerebrovascular diseases. Epidemiologic studies demonstrated a preventative effect of dietary polyphenols toward cardiovascular disease. In studies using cultured vascular ECs, polyphenols were recognized to regulate nitric oxide and endothelin-1 (ET-1) production. Furthermore, epigallocatechin-3-gallate inhibited the expression of adhesion molecules by a signaling pathway that is similar to that of high-density lipoprotein and involves induction of Ca2+/calmodulin-dependent kinase II, liver kinase B, and phosphatidylinositol 3-kinase expression. The effects of polyphenols on ECs include antioxidant activity and enhancement of the expression of several protective proteins, including endothelial nitric oxide synthase and paraoxonase 1. However, the observed effects of dietary polyphenols in vitro do not always translate to an in vivo setting. As such, there are many questions concerning their physiological mode of action. In this review, we discuss research on the effect of dietary polyphenols on cardiovascular disease and their protective effect on EC dysfunction.
血管内皮细胞功能障碍是心脑血管疾病发生的重要诱因。流行病学研究表明，膳食多酚对心血管疾病有预防作用。在使用培养血管内皮细胞的研究中，多酚被认为可以调节一氧化氮和内皮素-1 (ET-1)的产生。此外，表没食子儿茶素-3没食子酸酯通过一种类似于高密度脂蛋白的信号通路抑制粘附分子的表达，该信号通路涉及Ca2+/钙调素依赖性激酶II、肝激酶B和磷脂酰肌醇3激酶的表达。多酚对内皮细胞的影响包括抗氧化活性和增强内皮一氧化氮合酶和对氧磷酶1等多种保护蛋白的表达。然而，在体外观察到的饮食多酚的影响并不总是转化为体内环境。因此，关于它们的生理作用模式有许多问题。本文就膳食多酚对心血管疾病的影响及其对EC功能障碍的保护作用进行综述。
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https://www.sciencedirect.com/science/article/abs/pii/S0899900714002032
