Supplementing Diet with Blackberry Extract Causes a Catabolic Response with Increments in Insulin Sensitivity in Rats
Abstract
Blackberry (Rubus sp.) fruit has a high content of anthocyanins, but its health benefits have not been sufficiently explored in healthy individuals. Thus, the aim of the study was to determine the effects of blackberry extract on lipid and glucose variables in female and male rats. Sprague Dawley rats were given a standard pellet (SD) or cafeteria (CD) diet supplemented (SD+R and CD+R) or not with Rubus extract for 80 days. Female rats given SD+R had lower body and liver weights than SD females; both sexes given SD+R showed lower plasma glucose and insulin, higher plasma NEFA, glycerol and 3-hydroxybutyrate, and higher liver concentration of triacylglycerols than SD rats. The homeostasis model of insulin resistance (HOMA) was lower in SD+R rats than in SD rats, but higher in CD rats. No effects of Rubus extract were observed in CD rats. In conclusion, Rubus extract, in rats given SD, decreased glycemia and increased insulin sensitivity. It also increased lipid breakdown in adipose tissue. The effects were greater in females than in males. No effect was seen in rats given CD, probably as a result of their high insulin resistance.
黑莓(Rubus sp.)果实花色苷含量高，但其对健康的益处尚未得到充分的探索。因此，本研究的目的是确定黑莓提取物对雌性和雄性大鼠血脂和葡萄糖变量的影响。给SD大鼠喂食标准颗粒(SD)或添加(SD+R和CD+R)或不添加黑莓提取物的餐厅(CD)饲料，连续80 d。给予SD+R的雌性大鼠体重和肝脏重量均低于SD雌性大鼠;与SD大鼠相比，两性SD+R组血糖和胰岛素水平均较SD大鼠低，血浆NEFA、甘油和3-羟基丁酸水平较高，肝脏甘油三酯浓度较高。SD+R大鼠胰岛素抵抗稳态模型(HOMA)较SD大鼠低，而CD大鼠较高。悬钩子提取物对乳糜泻大鼠无明显影响。综上所述，黑莓提取物可降低SD大鼠血糖，提高胰岛素敏感性。它还增加了脂肪组织的脂质分解。这种影响在女性身上表现得比男性更明显。在给予乳糜泻的大鼠中没有发现影响，可能是由于它们的高胰岛素抵抗。
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