Blood–brain barrier transport and neuroprotective potential of blackberry-digested polyphenols: an in vitro study
Purpose
Epidemiological and intervention studies have attempted to link the health effects of a diet rich in fruits and vegetables with the consumption of polyphenols and their impact in neurodegenerative diseases. Studies have shown that polyphenols can cross the intestinal barrier and reach concentrations in the bloodstream able to exert effects in vivo. However, the effective uptake of polyphenols into the brain is still regarded with some reservations. Here we describe a combination of approaches to examine the putative transport of blackberry-digested polyphenols (BDP) across the blood–brain barrier (BBB) and ultimate evaluation of their neuroprotective effects.
流行病学和干预研究试图将富含水果和蔬菜的饮食对健康的影响与多酚的消费及其对神经退行性疾病的影响联系起来。研究表明，多酚可以穿过肠道屏障，在血液中达到浓度，从而在体内发挥作用。然而，多酚对大脑的有效吸收仍有一些保留。在这里，我们描述了一种检测黑莓消化多酚(BDP)穿越血脑屏障(BBB)假定运输和最终评估其神经保护作用的方法组合。
Conclusions
BBB transport of BDP and hBDP components reinforces the health benefits of a diet rich in polyphenols in neurodegenerative disorders. Our results suggest some novel pathways and genes that may be involved in the neuroprotective mechanism of the BDP polyphenol components.
BDP和hBDP成分的血脑屏障运输加强了富含多酚的饮食对神经退行性疾病的健康益处。我们的研究结果表明，BDP多酚组分的神经保护机制可能涉及一些新的途径和基因。
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