Gastroprotective Effects of Plants Extracts on Gastric Mucosal Injury in Experimental Sprague-Dawley Rats
Rubus crataegifolius (black raspberry, RF), Ulmus macrocarpa (elm, UL), and Gardenia jasminoides (cape jasmine, GJ) are well known for hundreds of years as folk medicines in China and Korea to treat various gastrointestinal disturbance. The present study evaluated the gastroprotective effects of these plants either single or in combination against HCl/EtOH-induced gastritis and indomethacin-induced ulcer in ratmodel. Stomach ulcer was induced by oral ingestions ofHCl/EtOHor indomethacin. Treatment with RF, UL, and GJ separately or in combination was done 1 h before ulcer induction. On HCl/EtOH-induced gastritis RF, UL, and GJ at a dose of 150mg/kg showed comparable antigastritis effect (less than 50% inhibition) with lesion index of 94.97±8.05, 108.48±11.51, and 79.10±9.77mmcompared to cimetidine (45.33±23.73 mm). However, the combination of RF, UL, and GJ at a dose of 150mg/kg with a ratio of 50:50:50 showed remarkable antigastritis effect with 77% inhibition.The observed lesion index at a ratio of 50:50:50 was 23.34±9.11mmsimilar to cimetidine (18.88±19.88 mm). On indomethacin-induced ulcer, RF and GJ showed 38.28% and 51.8% inhibition whereas UL showed around 17.73% inhibition at 150mg/kg. Combination of RF, UL, and GJ at 150mg/kg showed strong antigastritis effect with 83.71% inhibition.These findings suggest strong gastroprotective effect of combined extract.
- 悬钩子(Rubus crataegifolius，黑覆盆子，RF)、大果榆(榆树，UL)和栀子(栀子花，GJ)作为中国和韩国众所周知的民间药物，用于治疗各种肠胃紊乱。本研究评价了这些植物单独或联合应用对HCl/ etoh诱导的胃炎和吲哚美辛诱导的溃疡模型大鼠的胃保护作用。口服盐酸吲哚美辛引起胃溃疡。溃疡诱导前1 h给予RF、UL、GJ单独或联合治疗。对HCl/ etoh诱导的胃炎，150mg/kg剂量下RF、UL和GJ的抗胃炎作用与西咪替丁(45.33±23.73 mm)相当，损伤指数分别为94.97±8.05、108.48±11.51和79.10±9.77mm，抑制率小于50%。而RF、UL、GJ联合用药，剂量为150mg/kg，比例为50:50:50，抗胃炎作用显著，抑制率为77%。病灶指数(50:50:50)为23.34±9.11mm，与西咪替丁(18.88±19.88 mm)相似。在150mg/kg剂量下，RF和GJ对吲哚美辛溃疡的抑制率分别为38.28%和51.8%，而UL的抑制率约为17.73%。RF、UL、GJ联合应用150mg/kg抗胃炎作用较强，抑制率达83.71%。提示复方提取物具有较强的胃保护作用。
In addition, these plants showed significant antioxidant activity in DPPH scavenging assay and antilipid peroxidation activity. Combination of black raspberry, elm, and cape jasmine might be a significant systemic gastroprotective agent that could be utilized for the treatment and/or protection of gastritis and gastric ulcer.
此外，这些植物在DPPH清除试验和抗脂质过氧化试验中表现出显著的抗氧化活性。黑覆盆子、榆树和栀子可能是一种显著的系统性胃保护剂，可用于治疗和/或保护胃炎和胃溃疡。
Read More
