Effects of blackberry (Morus nigra L.) consumption on serum concentration of lipoproteins, apo A-I, apo B, and high-sensitivity-C-reactive protein and blood pressure in dyslipidemic patients

Background:

This study investigated blackberry (Persian mulberry) effects on apo A-I, apo B, high-sensitivity-C-reactive protein
(hs-CRP), and systolic blood pressure (SBP) and diastolic blood pressure (DBP) in dyslipidemic patients.

Materials and Methods:
In this 8-week randomized clinical trial, 72 dyslipidemic patients were randomly divided into two groups: Intervention (300 mL/day blackberry juice with pulp) and control group (usual diets). Before and after the intervention, fasting blood samples were taken from both groups and serum concentration of lipoprotein, apo A-I and apo B, serum lipids (total cholesterol, low-density lipoprotein, highdensity lipoprotein [HDL], and triglyceride), hs-CRP were measured. Blood pressure before and after the study was measured with a mercury manometer. Results: At week 8 in the intervention group, apo A-I and HDL increased significantly (P = 0.015, P = 0.001, respectively), apo B and hs-CRP decreased significantly (P = 0.044, P = 0.04, respectively). Mean changes in apo A-I and HDL and apo B/apo A-I ratio were significant between the groups (P = 0.005, P = 0.014, and P = 0.009, respectively). After 8 weeks, there was a significant difference between hs-CRP mean values (P = 0.01) of the groups. At week 8, SBP decreased significantly (P = 0.005) in the intervention group with no significant differences for SBP mean values between the groups. No significant changes were observed in other lipid parameters and DBP in the intervention group and between the groups.

Conclusion:

Blackberry consumption may exert beneficial effects on apolipoproteins, blood pressure, and inflammatory markers in individuals with lipid disorders.

 

背景:本研究研究了黑莓(波斯桑)对载脂蛋白A-I、载脂蛋白B、高敏c反应蛋白的影响(hs-CRP)、收缩压(SBP)和舒张压(DBP)。

材料与方法:在这项为期8周的随机临床试验中，72例血脂异常患者被随机分为两组:干预组(300 mL/天含果肉的黑莓汁)和对照组(常规饮食)。干预前后，两组均取空腹血样，测定血清脂蛋白、载脂蛋白A-I、载脂蛋白B浓度、血脂(总胆固醇、低密度脂蛋白、高密度脂蛋白[HDL]、甘油三酯)、hs-CRP。研究前后的血压都用水银压力计测量。结果:干预组第8周时，载脂蛋白A-I、HDL显著升高(P = 0.015, P = 0.001)，载脂蛋白B、hs-CRP显著降低(P = 0.044, P = 0.04)。两组间载脂蛋白A-I、HDL和载脂蛋白B/载脂蛋白A-I比值的平均变化均有显著性差异(P = 0.005、P = 0.014和P = 0.009)。8周后，各组hs-CRP均值差异有统计学意义(P = 0.01)。第8周，干预组收缩压显著降低(P = 0.005)，两组收缩压均值无显著差异。干预组及两组间其他脂质参数及舒张压无明显变化。

结论:食用黑莓可能对血脂紊乱个体的载脂蛋白、血压和炎症标志物有有益的影响。

 

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https://www.cabdirect.org/?target=%2fcabdirect%2fabstract%2f20143106305